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General
  • Taxus brevifolia and named it 'taxol'. When Bristol-Myers Squibb (BMS) licensed the compound for sale they claimed rights to the name as well and people responded by referring to the generic name as 'paclitaxel'.
  • Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute
  • Taxol, a potent anticancer natural product (with activity against a number of leukeamias and solid tumours in the breast, ovary, brain, and lung in humans) has stimulated an intense research effort over recent years.

Process

  • Bioxel’s new SMB process has increased product yield and through-put, removed other trace impurities and has reduced or eliminated undesired solvents.
  • Bioxel found that the best strategy for purification was to push cephalomannine together with paclitaxel as far as possible through the process, favoring high paclitaxel yield along the way. 

  • A process was licensed and developed to produce taxol by Bristol Myers.

Technology

  • Bioxel recently installed an SMB purification process, using equipment built by Groupe NovaSep .

  • Bioxel found that the best strategy for purification was to push cephalomannine together with paclitaxel as far as possible through the process, favoring high paclitaxel yield along the way.

  • Currently a cell culture method developed by Phyton Catalytic [now a division of DFB Pharmaceuticals] is used by BMS to produce taxol.

Application

  • The median plasma clearance (CLtot) increased significantly from 240 ml/min for the taxol application to 340 ml/min for LEP-ETU (30% increase, p = 0.002).

  • taxol application could enhance axonal growth of neurons cultured on an inhibitory substrate.

  • Taxol application interferes with the formation of retraction bulbs

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