Taxus brevifolia and named it 'taxol'. When
Bristol-Myers Squibb (BMS) licensed the compound for sale they claimed
rights to the name as well and people responded by referring to the
generic name as 'paclitaxel'.
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was
discovered in a National Cancer Institute program at the Research
- Taxol, a
potent anticancer natural product (with activity against a number of
leukeamias and solid tumours in the breast, ovary, brain, and lung in
humans) has stimulated an intense research effort over recent years.
recently installed an SMB purification process, using equipment built by
Groupe NovaSep .
found that the best strategy for purification was to push cephalomannine
together with paclitaxel as far as possible through the process,
favoring high paclitaxel yield along the way.
Currently a cell
culture method developed by Phyton Catalytic [now a division of DFB
Pharmaceuticals] is used by BMS to produce taxol.
taxol application could
enhance axonal growth of neurons cultured on an inhibitory substrate.
interferes with the formation of retraction bulbs
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