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Information @ a Glance

General

  • Transdermal delivery of a drug product which is currently approved as oral dosage form, allows for the avoidance of first pass metabolism by the liver and the delivery of a more even level of the therapeutic agent over the course of 24 hours. Dermal patches are the most common form of transdermal delivery of drugs.
  • Transdermal drug delivery provides excellent control of the rate of delivery directly into the bloodstream. It also offers a predictable pharmacokinetic profile and constant drug levels over extended periods of time without the extreme peak/trough fluctuations inherent in oral administration. And discontinuation of therapy can be achieved immediately by simply removing the patch

Technology

  • Transdermal delivery of therapeutic agents has been used successfully for several decades. Transdermal systems for hormone replacement therapy, smoking cessation, and pain management are well accepted; however, there have been challenges in expanding use of the technology to the delivery of peptides, proteins, and other macromolecules.
  • Throughout the past 2 decades, the transdermal patch has become a proven technology that offers a variety of significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood-level profile, resulting in reduced systemic side effects and, sometimes, improved efficacy over other dosage forms. In addition, because transdermal patches are user-friendly, convenient, painless, and offer multi-day dosing, it is generally accepted that they offer improved patient compliance

Uses

  • Transdermal delivery of medications to veterinary patients is becoming increasingly popular. An effective, non-invasive method of medicating animals is welcomed by veterinarians and owners alike.
  • Advances in molecular biology have given us a wide range of protein and peptide-based drugs that are unsuitable for oral delivery because of their high degree of first-pass metabolism. Though parenteral delivery is the obvious answer, for the successful development of commercial chronic and self-administration usage formulations it is not the ideal choice. Transdermal delivery is emerging as the biggest application target for these agents, however, the skin is extremely efficient at keeping out such large molecular weight compounds and therapeutic levels are never going to be realistically achieved by passive absorption.

Market

  • The market for transdermal products has been in a significant upward trend that is likely to continue for the foreseeable future. While it is true that product approvals for new Transdermal drug delivery products have not exploded as some predicted following the rapid success of Transdermal drug delivery nicotine products in the early and mid 90s, an increasing number of Transdermal drug delivery products continue to deliver real therapeutic benefit to patients around the world.
  • The outlook for continued growth of the Transdermal drug delivery market is very optimistic. Market analysts forecast a low double-digit compound annual growth rate for the US Transdermal drug delivery market throughout the next decade. Given the recent trend and product pipeline, this may actually under predict the potential of the Transdermal drug delivery market throughout this time period

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