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Information @ a Glance

General
  • Yohimbine chloride -- a standardized form of yohimbine-- is a prescription medicine that has been used to treat erectile dysfunction
  • Yohimbine hydrochloride is the standardized form of yohimbine that is available as a prescription medicine in the United States, and has been shown in human studies to be effective in the treatment of male impotence.

Process

  • The yohimbe tree is a tall evergreen that is native to western Africa. The bark of the tree contains a chemical called yohimbine. The amount of yohimbine in dietary supplements may vary; some yohimbe products have been found to contain very little yohimbine.
  • The levels of yohimbine that is present in yohimbe bark extract are variable and often very low.

Applications

  • The yohimbine alkaloids have been widely employed as folk medicines, the former serving as a cure for snake bites and a sedative, the later finding applications as a fertility drug and an aphrodisiac.
  • It is also known that yohimbine is contraindicated with MAO inhibitors, which are often to be found in the action of many anti-depressants. Thus, a physician's advice should be sought before starting on yohimbine, if you are taking any form of anti-depression therapy.
  • A novel affinity resin, yohimbine-agarose, was synthesized and used for purification of a2-adrenerrgeicceptors.

Technology

  • a2-Adrenoreceptor mimics, prepared by molecular imprinting technique of yohimbine, were used to select ligands from a phage display hexapeptide library.
  • Phosphorimetry has been established as a powerful technique for the trace determination of organic molecules. In this work, a room temperature Phosphorescence based analytical method was devaloped for the selective determination of yohimbine.

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